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Depression in Pregnancy
Depression is the most common psychiatric disorder, so it's a commonly encountered
pre-existing condition during pregnancy. Additionally, women have
it twice as often as men, and among women, there is an increased tendency
toward it during the reproductive years. Where the menstrual cycle
fits in as a contributing factor is unknown, as we've still only just scratched
the surface of the whole PMS mystery. Certainly borderline depression
can be affected by the hormonal impact of the menstrual cycle.
And
by pregnancy, too.
Pregnancy
is a particularly fertile field for depression to either start anew or
worsen if already a problem. The extra physical, financial, marital,
and sexual stresses come whether one is ready or not. On top of that,
any new feelings of poor self-image can reinforce depression's already
negative self-image problems.
An
obstetrician is qualified to handle mild depression, anxiety, "the blues,"
and general moodiness. But severe depression is a very serious illness
that requires the additional care of a psychiatrist, because many people
die from it! I'm talking about suicide, so all moodiness should be
questioned.
Depression
diagnosis can often be a confusing challenge. For instance, a common
cause (co-illness?) of depression is thyroid disorder. Many women
who have hypothyroidism will present first as a depressed patient, so thyroid
function testing is a very good idea in anyone complaining of depression.
Also, depression can be over-diagnosed. For instance, if a woman's
husband has just died in a car crash, her house has burned down, and she's
been mugged and beaten up recently, depression is probably not an illness
but a reasonable reaction to these things.
The
point of this ridiculous example is that it's not inappropriate to be bummed
out over really bad things in one's life. Clinical depression, on
the other hand, is when there is an inappropriate reaction to things, known
or unknown.
Predisposing factors that make depression more likely are:
- Childhood trauma, like death or illness of a parent or sibling
- Childhood sexual abuse, which will distort the well-being of a person
on many levels
- Family history of depression
- Lower socioeconomic status (translated, poverty)
- Stress
- Substance abuse
In any new depression during or after the pregnancy, it's important to tell the difference between merely "feeling depressed" and clinical depression.
Feeling Depressed
After
delivery, feeling depressed may respond to an understanding ear and a reassurance
that this is common. What a new mother (and father) fail to anticipate
is a selfish inner rebellion to the fact that they've been pushed to the
#2 (or #3) position in the family and can't just do whatever they want
anymore. For instance, let's take movies. As a couple you pretty
much see all of the movies you really want to see either at the theater
or on cable or tape. Along comes baby.
Forget
movies. No movies for about two years! And this is a colossal
drag since life has been one big date up till now. Now, you can even
forget seeing a movie at home uninterrupted by feedings or diapers or just
checking on a suspiciously quiet baby. And if you go someplace, no
more just hopping into the car and goin'. You've got to haul all
of this stuff along: packages of diapers, wipes, blankets, clicky toys, and
the like. And as the baby gets older, add to this haul of paraphernalia
collapsible rolling pods, strollers (two varieties the deluxe and the umbrellas),
medicines, and snap containers of gruel.
It
won't get any better until you realize and accept the new world order:
You just have to put your
life on hold for a couple of years.
On the
surface, this is a bitter disappointment to your own inner child who wants
to shuck & jive and rock & roll; but your thinking parental brain knows
better--you are now a family and you're doing this for your children.
Fulfillment in life trust me is much better than just having a lifetime
of fun.
During
pregnancy, feeling depressed is usually a problem in which a woman, once
feeling fit, experiences nagging physical complaints caused by something
she has no control over. As a woman's abdomen expands in the mirror,
this physical sign is symbolic of a shift from seeing herself as a woman
to seeing herself as a mother. From seeing herself as a sexual being
to seeing herself as a maternal one.
"What have
I gotten myself into?" isn't a question with a remedy, unfortunately, except
for the cruel, "Deal with it." And because, I'm told, men are from
Mars, they're often not the most sympathetic persons and often fail to
come through. However, a couple who are pregnant for all of the right reasons
or who have put themselves into the big picture of what pregnancy is all
about will ultimately find a way to stay afloat on this endless sea of
uncertainty. It's a "sea-legs" sort of thing and a matter of self-perspective.
If the relationship between the expectant parents is good, mild depression
need only be a temporary reaction to a permanent change in one's life.
Clinical Depression
Alterations
in thinking, delusions, or hallucinations, however, push the diagnosis
of depression, categorically, into a psychosis. After delivery, postpartum
depression is a serious illness to be distinguished from the "postpartum
blues." Thought disorder can get fairly creepy in that the mother starts
having threatening thoughts about the baby. But a woman so
afflicted isn't any more afflicted after birth than she would be any other
time if she's got a history of mood disorders. According
to the American
College of Obstetricians and Gynecologists, Technical Bulletin 182,
"Depression in Women,"
"Major clinical depression has been
thought to be more common following childbirth than during other periods
of a woman's life. However, current studies do not substantiate this
belief. Women at risk for significant postpartum depression are more
likely to have a family history of depression, a previous postpartum depression,
or significant adjustment problems with childbirth. It has been demonstrated
that women who have a planned pregnancy in a secure environment, enjoy
a supportive relationship with their partner, and have manageable levels
of life stress are less likely to experience postpartum depression."
And
to her marriage. Often a new father, dealing with issues of the new
world order himself, won't understand why such a wonderful time is being
ruined by a bad mood, an attitude, or anger misdirected at the most likely
victim in this drive-by shooting: him! Obstetricians, nurses, social
workers, midwives, doulas even lactation nurses can be a crucial help in
recognizing depression and counseling a husband on the pathology involved
and how this illness needs as much patience as convalescence from any physical illness.
During
pregnancy, real depression is a high risk situation which tends to make
patients prone to non-compliance with their prenatal care (keeping appointments,
eating right, doing what's best for the baby). Substance abuse, either
prompting the depression or because of it, doesn't mix well with a developing
baby. The legitimate drugs for depression are also a concern, but
they are weighed as a risk vs. benefit decision. But in true depression,
the benefit usually far outweighs any potential risks.
The
woman who is doing fine on today's anti-depressants but then gets pregnant
will have worries over what a particular medicine might do to her baby.
Luckily, there's been an explosion of effective and for the most part safe
antidepressant drugs over the last fifteen years, and most of these patients
will be on the newer, modern drugs. The seriously depressed patient
may still present on the older stuff, however, and a switch to a safer
medicine may present risks of worsening her condition.
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DRUGS FOR DEPRESSION DURING
PREGNANCY
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(The American Academy
of Pediatrics feels the permanent effects of antidepressants on the nursing
infant to be unknown and therefore doesn't officially sanction their safety
at this time.) |
Below is a simple review of drugs used for
both clinical depression and the simpler mood disorder of "feeling depressed."
The New Stuff The
"selective serotonin re-uptake inhibitors" (SSRIs)
These drugs keep the levels of serotonin higher in the brain. Serotonin
is a neurotransmitter that rises and falls, affecting mood and well-being.
These medicines decrease the amount of serotonin that is reabsorbed, keeping
the levels higher and constant.
|
Zoloft (sertraline ) |
FDA Class B.
Probably safe. |
| Prozac
(fluoxetine) |
FDA Class B. Probably safe.
There's more data on
Prozac than Zoloft, prompting one
to think that Prozac may be safer.
But it's just that there's more
data exonerating the Prozac . |
| Paxil
(Paroxetine) |
FDA Class D. Not recommended as there is evidence of fetal harm. |
| Luvox
(fluvoxamine) |
FDA Class B. Probably safe.
This drug not only keeps levels of serotonin up, but also decreases the
re-uptake of dopamine, another "feel good" neurotransmitter. In fact,
dopamine is the neurotransmitter that is especially high in addictions,
and its fall is associated with the unpleasant physical suffering called
withdrawal. This is the whole idea behind using Wellbutrin (aka,
Zyban) (a dopamine re-uptake inhibitor) to quit smoking (see next
line). |
| Wellbutrin,
Zyban
(Bupropion) |
FDA Class B. Probably safe,
and in fact it's safety has been well-established in that there haven't
been any reports of problems with it. |
| Effexor
(venlafaxine). |
FDA Class B. Probably safe.
This drug's actual mechanism is unknown, but it works probably by increasing
the neurotransmitter activity as well. There have been some concerns
regarding an increase in blood pressure with Effexor, and this side effect
would be particularly confusing in a pregnancy because of the usual vigilance
for Pregnancy-induced Hypertension (PIH, formerly called "toxemia" or "pre-eclampsia"). |
Anti-anxiety Agents
|
Buspar
(buspirone) |
FDA Class B. Probably safe.
As described above, this decreases the re-uptake of dopamine. |
| Atarax
(or Vistaril) (Hydroxyzine) |
FDA Class C. There's a small
possibility of abnormalities if given during the first trimester.
But Vistaril is a popular anti-nausea drug that is used commonly during
pregnancy. In my practice, I will just try to avoid it during the
first trimester, and I don't generally use this as a first choice for anxietyuspar
being a better choice. |
| Xanax |
FDA Class D. See below, "The
bad guys in pregnancy." |
The Bad Guys in Pregnancy
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Valium
(diazepam) |
FDA Class D. Not recommended.
Quick to reach the fetus, but slow to clear, this drug has been associated
with facial development abnormalities, cleft lips and palates, growth retardation...Do
I need to go on? These warnings are for the chronic use or abuse
of Valium. (Using it acutely in a seizure situation probably doesn't
have the same dangersot to mention that using it for dire emergencies
is better than not using it.) |
| Xanax
(Alprazolam) |
FDA Class D. Not recommended.
This drug is related to Valium and all of the above apply. In my
practice, I've found it more addictive than the serotonin-re-uptake inhibitors.
(Actually, I've never had trouble getting patients off of the serotonin-re-uptake
inhibitors; but I can't say the same for Xanax. Of
course, in all fairness to Xanax,
it's probably used most frequently against labeling instructions.) |
| Dalmane
(Alprazolam) |
FDA Class D. Same story, it's
an "-azepam" drug. In fact, it's a good idea to stay away from any
drug whose generic name ends in "-azepam." Dalmane is usually
used as a sleeping pill. Withdrawal in newborns is always a possibility
with the "-azepams." |
| Ativan
(lorazepam) |
Lorazepam is a benzodiazepine.
Lump it in with the above "bad guys." |
| Tranxene
(chlorazepate) |
also an "-azepam," actually,
a "-diazepine". Stay away from it, too. |
The Older Stuff
|
Elavil (amitriptyline) |
FDA Class D. Probably safe,
but it earns the "D" status because there have been rare reports of deformities.
"Safe for most pregnancies" doesn't reassure the one person whose
baby is affected adversely. |
| Tofranil
(Imipramine) |
FDA Class D. Same story as
Elavil. Also, one mustn't forget the withdrawal a newborn may suffer
at the hands of these drugs. |
In The Real World
So in a typical ObGyn practice,
what's typical?
The SSRIs
are so safe, it seems, that I'll use them (especially Wellbutrin and Prozac)
during the 2nd and 3rd trimesters even for mild depression if the depression
is interfering with a patient's happiness. I won't venture so casually
into the 1st trimester unless the depression is severe. If severe
depression involves any type of thought disorder, I'll insist that a psychiatrist
be involved.
Breastfeeding
risks of using depression drugs should be left to the Pediatrician.
If the benefit of the drug during breastfeeding outweighs the risk, still
the new mother may want to switch to formula so that she can treat herself
without worry.
Outside
of pregnancy and breastfeeding, I feel that the SSRIs are a very safe drug
class and use them for anything from PMS (now melodramatized as "premenstrual
mood dysphoria") to depression. Interestingly, Prozac is now available
as Sarafem for PMS the subject of another article.
For
just anxiety in the non-pregnant woman (without depression), I prefer Buspar
or the newer Celexa, and I don't usually use Xanax, Valium, or the diazepam
class. This is because anxiety tends to be a long term problem, and
the diazepam class is not a safe long term drug because of the addictive
potential.
Plot Thickens
The
neurotransmitter aspect of treating disorders is all the rage in pharmaceutical
research. Just take serotonin, for instance. There are some
serotonin receptors that affect mood, some that affect appetite (the SSRI
Meridea is used in dieting), and other receptors that do other things.
The SSRIs hint at an exciting growth direction for drugs for many diseases.
True, we've had our disasters (the Redux fiasco years ago which resulted
in heart damage), but for the most part this direction has yielded many
safe drugs that seem to have minimum risk in pregnancy.
That's
good news, because pregnant people get sick, too.
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